In Yandere Simulator, the title of 'Senpai' is given to the young man (or young woman) that the protagonist is infatuated with.
If you start working at a new job, any co-worker who has been employed at the workplace longer than you is your 'senpai'. For example, if you are a first-year student, all second-year and third-year students are your 'senpai'.
'The Japanese word 'senpai' refers to someone who has seniority over someone else. Her placeholder name is Taeko Yamada, which is the female equivalent of her male counterpart.